Overview of Tests
Cosmetic Safety Testing and Hypoallergenic Claims
RIPT, Dermatologist, Opthalmologist Testing, etc. – ADVANCED provides a range of laboratory procedures specifically designed to evaluate the safety of products that contact the body.
RIPT (Repeat Insult Patch Test) for “Hypoallergenic” claim support – ADVANCED offers a standard 6-week RIPT to determine irritation and sensitization potential. Specialty 24- and 48-hour single-application patch tests are available as well as cumulative irritation patch tests designed to evaluate the primary irritation potential of test materials.
Use the links below to download our current RIPT schedules:
2025 RIPT SCHEDULE
RIPT (Repeat Insult Patch Test) data is derived from In-Vivo sample testing on panels of 50, 100, and up to 200 subjects to develop valuable information related to contact irritation and sensitization.Patch Test
- 24-hour Patch Test
- 48-hour Patch Test
- Cumulative Irritation 21-day examination
Upon request, physician signatures are available to support product claims. This includes “Dermatologist Tested” and “Pediatrician Tested” claims as well as for other specialties such as plastic surgery, ophthalmology and gynecology.
Human comedogenicity – Testing to establish the propensity of a topical formulation or ingredient to induce formation of sebum plugs (comedones/blackheads) in sebaceous glands. Visual and microscopic observations are carried out to determine the ratio of comedones to follicles present in the treated area before and after a series of occlusive or semi-occlusive product applications.
Use the links below to download our current Comedo testing schedules:
Phototoxicity – Testing to investigate the potential of a topically applied product to cause skin irritation when exposed to UV radiation. This study is recommended for products intended for extended skin contact in sunlight (outdoors).
Photomaximization (photoallergy maximization test) – The potential of topically applied products to develop irritation and/or sensitization in the presence of UV light used to simulate natural sunlight. For example, baby products, dry-skin and sensitive-skin care, geriatric and all-day moisturizers, etc.
Ophthalmologist tested – Exaggerated use studies – Physician-supervised, exaggerated-use studies designed for contact lenses and other eye-area products, including 28-day use; 50% contact lens wearers.
Facial sting/discomfort studies – Qualified panelists screened for relative sensitivity to commercial products to support “No Sting” and “Non-Irritating” claims.
Eye irritation/sting studies – Panelists can be instructed to report back the level of sting and irritation as a product comes in contact with the eye or the sensitive eye area to help support “No Tear” or “Tear Free” type claims.
Eye irritation studies can also be completed with our proprietary PhotoGrammetrix® technique.